In 1983, Poythress married Diane M. Poythress. They have two sons, Ransom Poythress and Justin Poythress.
As of 2016, he was teaching New Testament and occasional courses on the philosophies of science and language at Westminster Theological Seminary in Philadelphia, work he began in 1976. His blog with John M. Frame was listed in early 2018 as one of the top 50 Christian popular culture sites.
Poythress views scientific law as a form of the word of God. In 1976, Poythress wrote a chapter on "A Biblical View of Mathematics," in which he argued (among other things) that number is eternal because the Trinity is eternal. In a 1983 article, he suggested that mathematics is the rhyme of the universe. His philosophy of science draws on the work of Thomas Kuhn.
^Frame, John M. (2017). "Preface". In John M. Frame; Wayne Grudem; John J. Hughes (eds.). Redeeming the Life of the Mind: Essays in Honor of Vern Poythress. Wheaton, IL: Crossway. pp. ii–vii. ISBN978-1433553066.
^Per the Bowyer article, op. cit., Poythress has an "M Div, ThM, M Litt, and a ThD in various theological disciplines from Westminster Seminary, Cambridge University and the University of Stellenbosch respectively", but the specific dates and details that appear are as yet unsourced. John Frame's preface to the dedicatory essay volume, op. cit., confirms this degree, but does not have date information.
^Frame, John J.; Grudem, Wayne; Hughes, John J., eds. (2017). Redeeming the Life of the Mind: Essays in Honor of Vern Poythress. Wheaton, Illinois: Crossway. ISBN1433553031.